蔼玲在一次交通意外中身亡，得一雪魔以血续命，但必须要得一阴年阴月阴日之人与其相恋，才能还阳，德明因是全阴之人，正好配合蔼玲，奈何德明不从，法师茂叔透露玄机破解蔼玲之血魔咒语，德明女友家仪以姓名换取德明安全，蔼玲还阳未遂，愤然化身血魔攻击三人，一场人魔大战拉开序幕……
在第五部中参加裸奔大会的艾瑞克（John White 饰）如愿升入德维特所在的大学了，但他却因被女友甩掉而情绪低落，老爸甚至不惜拿出自己年轻时的“桃色名单”来为他打气。男女共用卫生间的大学生活果然疯狂，更有德维特领导的“贝塔”兄弟社定期举办狂欢派对，艾瑞克的压抑得到了缓解。然而贝塔兄弟社正面临一群校中精英人物创办的“GEK”兄弟会的冲击，而且艾瑞克等人还要准备加入贝塔所经历的五十个挑战。在艾瑞克埋头做任务的同时，贝塔与GEK的矛盾不断升级，最后发展到要用被学校禁止长达四十年的“古希腊运动会”决一胜负，这是一场关乎两个社团存亡的决战，兄弟会能够重现辉煌么？
The Most Unknown is an epic documentary film that sends nine scientists to extraordinary parts of the world to uncover unexpected answers to some of humanity's biggest questions. How did life begin? What is time? What is consciousness? How much do we really know? By introducing researchers from diverse backgrounds for the first time, then dropping them into new, immersive field work they previously hadn't tackled, the film reveals the true potential of interdisciplinary collaboration, pushing the boundaries of how science storytelling is approached. What emerges is a deeply human trip to the foundations of discovery and a powerful reminder that the unanswered questions are the most crucial ones to pose. Directed by Emmy-nominated and Peabody Award-winning filmmaker Ian Cheney (The Search for General Tso, The City Dark) and advised by world-renowned filmmaker Werner Herzog (Fitzcarraldo, Aguirre, The Wrath of God, Grizzly Man), The Most Unknown is an ambitious look at a side of science never before shown on screen. The film was made possible by a grant from Science Sandbox, a Simons Foundation initiative dedicated to engaging everyone with the process of science.
