上古时期妖兽纵横，一位神秘道人分别授予了阴阳五行的特殊能力给金木水火土五个家族来抵抗妖兽，他们将妖兽驱赶到神隐雾山之中，设立结界。 雾山之中另有被封印于巨阙神盾之中的具有强大灵力的麒麟兽，常常吸引来那些想要提升妖力突破结界的妖兽。火行使者闻人翊悬为救其母私自打开了巨阙神盾，小麒麟趁机偷溜出来，妖兽界将掀起一 股腥风血雨......
“上界之路，千难万险；破灭神国，踏平寰宇。千锤百炼，终将成神！” 罗征为复活挚爱宁雨蝶，踏上前无古人的逆天之路！天羽秘境与天穹生隙反目，却于神弃塔下并肩相守。爱恨难明，红颜淬骨；百炼封神，顺逆由己。飞升上界的罗征，势要挣脱天命枷锁，终成寰宇唯一天命人……然而，天命之外的死劫正悄然降临！
In the year 1524, the former Assassin Ezio Auditore retired to a villa in the countryside of Tuscany, with his wife Sofia and children Marcello and Flavia. While Ezio wrote in his study, Sofia asked him to watch Flavia while she and Marcello visit his sister Claudia. Shortly after, he left his study to tend their vineyards while Flavia played nearby the villa. In the midst of his harvest, he saw a stranger cloaked in black, talking to Flavia. Fearing the worst, Ezio hurriedly intercepted the stranger, though Flavia told him that she was no danger, as Ezio saw her necklace with the Assassin insignia...
