一日夫妻百日恩（高曙光版）

　　武林之中，“如来神掌”和“天蚕神功”被称为传奇，失传已久。一晃眼三百年过去，“如来神掌”重出江湖掀起了一场腥风血雨，人人都知道，只要夺得了如来神掌的秘籍，即是获得了掌控武林的金钥匙。
　　段飞（张智霖 饰）出身贫寒，又因为见义勇为而被人捉住了把柄失去了赖以生存的工作和住所，无奈之下，他只得投靠与自己有过一面之缘的老人火云邪神（孙兴 饰），却不知这位看似平凡的老人竟然就是江湖上人人得而诛之的魔头。一次偶然中，段飞邂逅了孤苦伶仃的屠雪华（朱茵 饰），两人渐渐坠入情网。某日，天蚕神功惊现江湖，而无辜的段飞再一次因此而背负上了不白之冤。

　　一家跨国制药公司“葛安公司”，与国内某沿海城市合作兴建了一座大型生物工程基地。西海医院院长徐谦，感觉到葛安在医院下属的肝病医疗中心干着某种非法药物实验的勾当，但对方组织极其严密，违法活动不着痕迹。徐谦又发现葛安的人还意图窃取自己的导师、在世界流行病领域享有盛誉的肝病中心主任凌知渊正在秘密研究的某项重大科研成果(“黑郁金香”病毒研究)。 　　职责和良知让徐谦决定查出黑幕。而最有效的办法就是让黑幕的操作者信任自己。此时，徐谦发现自己患了一种不治之症——肌肉萎缩症。他知道最多半年时间，他就将躺在病床上，而最多两年时间，他将辞别人世。徐谦义无反顾地上了葛安公司的“贼船”，经过一场对方精心策划的“考试”后，徐谦成了生物工程基地的CEO…… 　　葛安公司断定凌知渊手上的秘密研究具有极大的商业价值。于是他的女儿、高级流行病学专家凌子墨被从在国外的葛安总部派回了西海。她的身份是生物工程基地高级顾问，但总部的秘密意图，是让她慢慢接近其父手中的秘密研究，助其父一臂之力，并在她自己不知情的情况下，将医学情报透给葛安…… 　　凌子墨回到西海，发现自己深爱的徐谦变得世俗、陌生甚至可怕。此种情形下，凌子墨与以前的恋人、一个因嫉恶如仇颇具个性而显得不合时宜的律师汪晓寒渐渐走得较近，徐谦为了让自己深爱的女友能在自己死前重新找到感情归宿，刻意做出一些不近情理伤害凌子墨的事，令凌子墨痛苦万分。 　　与魔共舞的徐谦，忍受着女友和导师朋友同事的误会，忍受着身体的痛苦和心灵的折磨，将收集到的犯罪分子们的罪证，以“蜘蛛侠”的网名不断给凌子墨发去电子邮件，指引凌子墨慢慢勘破其中的种种“悬机”。徐谦成了一个特殊的卧底和两面人，他想通过这样的方式里应外合让凌子墨汪晓寒等人将犯罪黑幕大白于天下。 　　“黑郁金香”病毒即将大面积爆发，凌知渊和凌子墨父女二人联手攻关，欲抢在病毒爆发前彻底破译它的基因密码。一场对黑郁金香科研成果的争夺战开始倾于白热化。葛安不惜代价不择手段要获取凌知渊父女的基因图。而最后黄雀在后的竟是凌知渊的助手、一个表面医术平平实则是此中高手的虞雅琴！当凌子墨等人终于意识到蜘蛛侠其实是徐谦时，徐谦为了保护黑郁金香的珍贵资料和虞雅琴等人展开了殊死搏斗，最后壮烈牺牲…… 　　依据徐谦提供的重要证据，西海市市长一声令下，葛安公司的罪犯们被依法逮捕，无一漏网…… 　　而人们敬仰的医学专家凌知渊，为了抢救病人自己感染了病毒，献出了生命…… 　　美丽的海滨墓地前，人们络绎不绝地前来凭吊英雄，大海亦为之动容……

　　个性率直的黄玉芬（蔡少芬 饰）在公司的权利斗争中惨被上司乐文（钱嘉乐 饰）陷害而降职，芬自此视之为敌人。这时芬家中的杂货店因为业主林祖光（郑敬基 饰）收回将要关闭，玉芬的姐姐玉琴（梅小慧 饰）用尽办法希望祖光能打消收楼的念头，没想到乐文再次从中作梗，让玉芬与乐文的关系更陷入僵局。而就在这时，令玉芬更加恼火的是自己的弟弟玉得（邓少尊 饰）与乐文的妹妹乐惠（邝文珣 饰）相恋并发生了关系。
　　乐文因为女友的移情别恋而深受打击，玉芬不忍而安慰乐文，两人化敌为友。乐文极力撮合朋友家明（马德钟 饰）与玉芬，就在家明与玉芬即将结婚之际，玉芬发现原来乐文爱上了自己……

　　在江湖打滚多年的老千翟冠一(陈展鹏饰)，被师父司徒省(潘志文饰)召唤，与六位同门何正花(林夏薇饰)、伍柏义(陈山聪饰)、丁权(林子善饰)、李亨(徐荣饰)、吴世峰(黄长兴饰)及苏丽芬(赵希洛饰)一起观战，见证司徒省与骏昇娱乐城老板赌王霍骏昇(单立文饰)的一场世纪之战。这一战让冠一上了一课：「无情才是赢家」!
　　赌王之战完结后，「千门七杰」到娱乐城出任不同岗位，为危机四伏的娱乐城找出内奸。
　　冠一与正花因是次任务被逼朝夕相对，二人本是情侣，还发展至差点结婚的地步，可是冠一曾为得赌王冠军出卖正花，自此二人各不相干。
　　七人当中，冠一跟精通魔术的柏义合作多年，甚有默契，情同手足。冠一等人缩窄调查范围，深入调查与骏昇情同手足的助手林磊(黄子雄饰)，及骏昇的情人知己丘月华(陈秀珠饰)。
　　千头万绪，众人赫然发现另一条与骏昇及林磊有关的线索。原来娱乐城当年由骏昇、林磊与蒋天龙(吴岱融饰)建立，天龙是三人中的大哥，但已失踪多年，生死未卜，而骏昇亦是因天龙的失踪才成为娱乐城的主人。

　　In 2261, the Vorlons join the Shadow War, but their tactics become a concern for the alliance when the Vorlons begin destroying entire planets which they deem to have been "influenced" by the Shadows. Disturbed by this turn of events, Babylon 5 recruits several other powerful and ancient races (the First Ones) to their cause, against both the Shadows and the Vorlons. Captain John Sheridan returns to the station after escaping from Z'ha'dum, but at a price: barring illness or injury, he has only 20 years left to live. He is accompanied by a mysterious alien named Lorien who claims to be the oldest sentient being in the galaxy.
　　Hours before Sheridan's return, Garibaldi is rescued and returned to the station, in rather dubious circumstances. He is markedly more paranoid and suspicious of other alien races and of Sheridan than he was before.
　　Centauri Emperor Cartagia forges a relationship with the Shadows. Londo Mollari engineers the assassination of Cartagia and repudiates his agreement with the Shadows. Londo kills Mr. Morden and destroys the Shadow vessels based on the Centauri homeworld, in an attempt to save his planet from destruction by the Vorlons. Aided by the other ancient races, and several younger ones, Sheridan lures both the Vorlons and the Shadows into an immense battle, during which the Vorlons and Shadows reveal that they have been left as guardians of the younger races, but due to philosophical differences, ended up using them as pawns in their endless wars throughout the ages. The younger races reject their continued interference, and the Vorlons and Shadows, along with the remaining First Ones, agree to depart the galaxy forever.
　　After the Shadows are defeated Garibaldi leaves his post as security chief and works on his own as a "provider of information". He begins working for one William Edgars, a Mars Tycoon, who is married to Garibaldi's former love. While he works ever closer with Edgars, he becomes increasingly aggressive towards Sheridan and eventually leaves Babylon 5.
　　Minbar is gripped by a brief civil war between the Warrior and Religious castes. Delenn secretly meets with Neroon of the Warrior caste and convinces him that neither side can be allowed to win. She tells him that she will undergo a ritual wherein she will be willing to sacrifice herself, but will stop the ritual before she actually dies. When Neroon sees that she actually intends to go through the entire ritual, he rescues her and sacrifices himself instead, declaring that, although he was born Warrior, in his heart he is Religious.
　　As part of the ongoing conflict between Earth and Babylon 5, Garibaldi eventually betrays Sheridan and arranges his capture in order to gain Edgars' trust and learn his plans. Garibaldi later learns that Edgars created a virus that is dangerous to only telepaths. It is then revealed, that Garibaldi was actually abducted by the Psi-Corps at the end of Season 3 and re-programmed by Bester to provide information to him at the right time. Bester releases Garibaldi of his programming, and allows him to remember everything he has done since being kidnapped. Edgars is killed and his wife disappears, but is reunited with Garibaldi after the end of the war. Garibaldi helps free Sheridan and return him to the campaign to free Earth. An alliance led by Babylon 5 frees Earth from totalitarian rule by President Clark in a short but bloody war. This culminates in Clark's suicide and the restoration of democratic government. Mars is granted full independence, and Sheridan agrees to resign his commission. The League of Non-Aligned Worlds is dissolved and reformed into the Interstellar Alliance, with Sheridan elected as its first President and continuing his command of the Rangers, who are to act as a galactic equivalent of United Nations peacekeepers.
　　In the season finale, the events of 100, 500, 1000, and one million years into the future are shown, depicting Babylon 5's lasting influence throughout history. Amongst the events shown are the political aftermath of the 2261 civil war, a subsequent nuclear war on Earth involving a new totalitarian government in the year AD 2762, the resulting fall of Earth into a pre-industrial society, the loss and restoration of humanity's knowledge of space travel, and the final evolution of mankind into energy beings similar to the Vorlons, after which Earth's sun goes nova.