电视动画《大剑》改编自八木教广创作的同名漫画，动画由Mad House负责制作。2007年4月4日起在日本电视台首播，全26话。
传说，从古至今妖魔就潜藏在人类的世界中，人类对妖魔完全束手无策，于是求助妖魔猎人。妖魔猎人是身材苗条背着巨剑的银瞳女子，她们的身体里混有妖魔之血，可算是半人半妖。因背着巨大的剑，人们故而称呼她们为“大剑”。本作故事正是围绕着大剑中的一员克蕾雅和人类少年拉基，以及其他大剑成员的相遇相知而展开的冒险故事。
桃夭带着小和尚磨牙、第一季收服的小狐妖、桃都老邻居柳公子一起，为了寻找失踪的百妖谱而云游四方。在途中遇到应声、化蛇、媪姬、照海四个妖怪，为妖怪治疗各种疑难杂症。
大三学生叶不凡，为了给母亲筹集医药费碰瓷，不料遇到不按套路出牌的女司机，被撞之后的叶不凡无意中穿越到幻境，获得了古医门的传承，从此精通医术、修炼功法，获得无数美女青睐。
被孤儿院赶出、濒临饿死边缘的少年中岛敦与一群风格奇异的男人们相遇了。
Adam's older brother was killed in a car crash a year ago. His family has not been the same since. As his parents struggle to cope with their grief, Adam (10), plagued with guilt over his brother's death feels he is all alone in the world. But everything changes the day he meets Abulele. The Abulele are ancient monsters, bear-sized. Local legends tell that they are extremely dangerous, but in fact, they turn out to be quite friendly and playful creatures. Abulele quickly becomes Adam's best and most secret friend. Together, they outsmart Adam's mean schoolteacher and beat the class bullies. But Adam's parents start to suspect he is harboring a secret, And when a government, Special Forces unit called "Thunder" appears in the neighborhood on a mission to capture Abulele things go from bad to worse. In order to save his best friend, Adam will have to get Abulele back home to its family, and to do so, he will need to put the past behind him and realize that when you truly love someone, ...
