故事开局看似平和，实则远非如此。两颗真心，三个人物，一段围绕身份困境苦苦挣扎的纠葛故事
CSI: New York, the third incarnation of the CSI: Crime Scene Investigation franchise, is a crime drama about forensic investigators who use high-tech science to follow the evidence and solve crimes in The Big Apple. Detective Mack "Mac" Taylor is a dedicated and driven crime scene investigator who believes that everything is connected and for everyone there is a story. He and his partner, Detective Stella Bonasera, a workaholic and a jack-of-all-trades, share a passion for the job. They lead a team of experts amid the gritty and kinetic city that never sleeps. Their team includes Danny Messer, a Brooklyn-born investigator with rugged good looks, an unflappable spirit and a colorful family history, and Dr. Sheldon Hawkes, a reclusive coroner who walked away from a promising surgical career after the traumatic loss of two patients. Joining them is homicide Detective Don Flack, an edgy, hardcore investigator with a quick wit, impressive forensic insight and limited patience with potential suspects. Rounding out the team is Aiden Burn, a smart and sexy investigator whose chameleon-like behavior allows her to adapt to any situation at any time. These skilled investigators, who see New York City in a whole different light, follow the evidence as they piece together clues and eliminate doubt to ultimately crack their cases.
Will Truman（艾瑞克·麦柯马克 Eric McCormack 饰）从哥伦比亚大学和纽约大学的法律专业毕业后，在一个一流的法律公司工作，目标是当上公司的合伙人。但后来辞职，决定开展自己的事业。Will最好的朋友Grace Adler（黛博拉·梅辛 Debra Messing 饰）拥有自己的室内装饰公司。两人在大学里认识的。经过短暂的交往后，Will意识到自己真正的性取向，两人和平分手，促成了一段美好的a gay- straight friendship。他们之间不用言语的沟通就可以明白对方心里所想，互相支持，互相理解，拥有最牢固的友情。
一次意外触发传送仪器，A时空的林晓希被传到了B时空，高冷博士周予恒为隐藏A时空林晓希的身份，为她出谋划策，A时空的林晓希一改往日软弱作风强势逆袭，正当A时空的林晓希和周予恒两人感情升温时，A时空的林晓希却即将消失在B时空。
崔珉植饰演由人生谷底反弹成赌场大亨，同命运对抗的斗士车武湜。熬过孤儿院、监狱、特殊部队嘅生活，再逃亡到菲律宾，赌到身无分文，史上最峰回路转的人生故事。
Mulder在医院被Fowley监管着。他想办法请来了Skinner和Kritschgau来帮忙，他们了解到Mulder拥有了CIA一直在研究的读心术。Scully在象牙海岸寻找治愈Mulder的办法。Mulder的病情加重了。
